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Paulus Kirchhof, MD

 

PERSONAL

Kirchhof_0309

Professor of Medicine (Cardiology), University of Münster, Germany
Attending Physician, Department of Cardiology, Hospital of the University of Münster, Germany, since 2007
BSc, University of Heidelberg, Germany, 1992
MD, University of Münster, 1997
Board exam of Medicine (Gebietsbezeichnung Innere Medizin), ÄKWL Münster, 2004
Board exam of Cardiology (Schwerpunktbezeichnung Kardiologie), ÄKWL, Münster, 2006
Co-Head, Cardiac Catheterization Laboratory, Dept of Cardiology, UK Münster, since 2008

 

HONORS AND AWARDS

1988: Stipend of the Town of Heidelberg for the Weizmann Summer Science Institute, Rehovot, Israel (Mathematical Modelling)
1990-1997: Scholarship of the Cusanuswerk (German catholic foundation for excellent students), alumnus since 1997
1994-1995: ERASMUS-Stipend of the European Union at University of Lille II, Lille, France
1998: Dissertation prize of the Heart Center Münster
2000: Founding member of collaborative reseach center (SFB) 556 „Heart failure and arrhythmias“, University of Münster
2002: Poster Prize of Einthoven Society at Symposium „100 years of ECG“, Einthoven
2003: Founding member (since 2004 member of steering committee) of the German Competence Network on Atrial Fibrillation (AFNET)
2004: Woldemar-Mobitz prize of the German Society of Cardiology
2005: Founding member of the SFB 656 „Molecular cardiovascular imaging“, member of the writing committee
2005: Sibylle-Hahne price for Medicine of the University of Münster
2005: Visiting scientist at the “German Mouse Clinic” of the German National Genome Research Network
2006: Bruno-Kisch price of the German Society of Cardiology
2007: Appointed Professor of Medicine, University of Münster, Germany.

 

EDITORIAL BOARDS

Editorial Board member of Heart Rhythm (2004- ...)
Editorial Consultant for the Lancet (2005 - ...)
Editorial Board member of Europace (2007 - ...)
Fellow of the European Society of Cardiology (2007 - ...)
Fellow of the Heart Rhythm Society (2008 - ...)

 

KEY PUBLICATIONS

  (* work related to the project; network members highlighted in bold)

  1. Kirchhof P, Fabritz CL, Franz MR (1998) Post-repolarization refractoriness versus conduction slowing caused by class I antiarrhythmic drugs - antiarrhythmic and proarrhythmic effects. Circulation, 97: 2567-2574.
  2. Kohl T, Kirchhof P, Gogarten W, Reckers J, Asfour B, Witteler R, Haverkamp W, Eckardt L, Marcus AE, Van Aken H, Breithardt G, Vogt J, Scheld HH (1999) Fetoscopic transeophageal electrocardiography and stimulation in fetal sheep - a minimally invasive approach aimed at diagnosis and termination of therapy-refractory supraventricular tachycardias in human fetuses. Circulation, 100: 772-776.
  3. Kirchhof P, Eckardt L, Loh P, Weber K, Fischer RJ, Seidl KH, Bocker D, Breithardt G, Haverkamp W, Borggrefe M (2002) Anterior-posterior versus anterior-lateral electrode positions for external cardioversion of atrial fibrillation: A randomised trial. Lancet, 360: 1275-1279.
  4. Knollmann BC, Kirchhof P, Sirenko SG, Degen H, Greene AE, Schober T, Mackow JC, Fabritz CL, Potter JD, Morad M (2003) FHC-linked mutant Troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling. Circ Res, 92: 428-436.
  5. Kirchhof P, Fabritz CL, Begrow F, Kilic A, Breithardt G, Kuhn M (2004) Ventricular arrhythmias, increased cardiac calmodulin kinase II expression, and altered repolarization kinetics in ANP-receptor deficient mice. J Mol Cell Cardiol, 36: 691-700.
  6. Kirchhof P, Mönnig G, Wasmer K, Heinecke A, Breithardt G, Eckardt L, Böcker D (2005) A trial of self-adhesive patch electrodes and hand-held paddle electrodes for external cardioversion of atrial fibrillation (MOBIPAPA). Eur Heart J, 26: 1292-1297.
  7. *Mueller FU, Lewin G, Baba HA, Boknik P, Fabritz L, Kirchhefer U, Kirchhof P, Loser K, Matus M, Neumann J, Riemann B, Schmitz W (2005) Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice. J Biol Chem, 280: 6906-6914.
  8. Kuhlmann M, Kirchhof P, Klocke R, Hasib L, Fabritz L, Stypmann J, Stelljes M, Tian W, Zwiener M, Mueller M, Kienast J, Breithardt G, Nikol S (2006) G-CSF/SCF reduces susceptibility to ventricular arrhythmias in the infarcted heart: potential role of regional connexin43 expression, arteriogenesis, and cardiomyocyte growth. J Exp Med, 203: 87-97
  9. Kirchhof P, Fabritz L, Zwiener M, Witt H, Schafers M, Zellerhoff S, Paul M, Athai T, Hiller KH, Baba HA, Breithardt G, Ruiz P, Wichter T, Levkau B (2006) Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice. Circulation, 114: 1799-1806.
  10. Wagner S, Dybkova N, Rasenack E, Jacobshagen C, Fabritz L, Kirchhof P, Maier SK, Zhang T, Hasenfuss G, Brown J, Bers DM, Maier LS (2006) Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest, 116: 3127-3138.
  11. *Kirchhof P, Auricchio A, Bax J, Crijns H, Camm J, Diener HC, Goette A, Hindricks G, Hohnloser S, Kappenberger L, Kuck KH, Lip GY, Olsson B, Meinertz T, Priori S, Ravens U, Steinbeck G, Svernhage E, Tijssen J, Vincent A, Breithardt G (2007) Outcome parameters for trials in atrial fibrillation: executive summary: Recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eur Heart J, 28: 2803-2817.
  12. Harzheim D, Pfeiffer KH, Fabritz L, Kremmer E, Buch T, Waisman A, Kirchhof P, Kaupp UB, Seifert R (2008) Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J, 27: 692–703
  13. Levkau B, Schafers M, Wohlschlager J, von Wnuck Lipinski K, Hermann S, Kawaguchi N, Kirchhof P, Fabritz L, Stypmann J, Stegger L, Flogel U, Schrader J, Fischer J, Hsieh PC, Ou YL, Merhof F, Tiemann K, Ghanem A, Matus M, Neumann J, Heusch G, Schmid KW, Conway EM, Baba HA (2008) Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation, in press.
  14. *Kirchhof P, Fortmueller L, Waldeyer C, Breithardt G, Fabritz L (2008) Drugs that interact with cardiac electro-mechanics: Old and new targets for treatment. J Progr Biophys Mol Biol, Vol. 97, pp 497-512.
  15. Kirchhof P, Fortmüller L, Waldeyer C, Breithardt G, Fabritz L (2008) Drugs that interact with cardiac electro-mechanics: old and new targets for treatment. Prog Biophys Mol Biol, 97(2-3): 497-512.
  16. Brüchert N, Mavila N, Boknik P, Baba HA, Fabritz L, Gergs U, Kirchhefer U, Kirchhof P, Matus M, Schmitz W, Depaoli-Roach AA, Neumann J (2008) Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality. Am J Physiol Heart Circ Physiol, 295(4): H1539-H1546.
  17. *Cosio FG, Aliot E, Botto GL, Heidbüchel H, Geller CJ, Kirchhof P, De Haro JC, Frank R, Villacastin JP, Vijgen J, Crijns H (2008) Delayed rhythm control of atrial fibrillation may be a cause of failure to prevent recurrences: reasons for change to active antiarrhythmic treatment at the time of the first detected episode. Europace, 10(1): 21-27.
  18. Harzheim D, Pfeiffer KH, Fabritz L, Kremmer E, Buch T, Waisman A, Kirchhof P, Kaupp UB, Seifert R (2008) Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J, 27(4): 692-703.
  19. Kirchhof P, Ozgun M, Zellerhoff S, Monnig G, Eckardt L, Wasmer K, Heindel W, Breithardt G, Maintz D (2009) Diastolic isthmus length and “vertical” isthmus angulation identify patients with difficult catheter ablation of typical atrial flutter – a pre-procedural MRI study. Europace, 11(1): 42-47.
  20. Knackstedt C, Schauerte P, Kirchhof P (2008) Electro-anatomic mapping systems. Europace, 10 (Suppl3): iii28-34.
  21. *Koebe J, Kirchhof P (2008) Novel non-pharmacological approaches for antiarrhythmic therapy of atrial fibrillation. Europace, 10(4): 433-437.
  22. Stehling C, Wersching H, Kloska SP, Kirchhof P, Ring J, Nassenstein I, Allkemper T, Knecht S, Bachmann R, Heindel W (2008) Detection of asymptomatic cerebral microbleeds: a comparative study at 1.5 and 3.0 T. Acad Radiol, 15: 895-900.
  23. Kirchhof P, Ozgun M, Zellerhoff S, Monnig G, Eckardt L, Wasmer K, Heindel W, Breithardt G, Maintz D (2009) Diastolic isthmus length and “vertical” isthmus angulation identify patients with difficult catheter ablation of typical atrial flutter – a pre-procedural MRI study. Europace, 11(1): 42-47.
  24. *Camm AJ, Kirchhof P, Lip G, Savelieva I, Ernst S (2009) Atrial fibrillation. In: The ESC textbook of Cardiology. Camm AJ, Serruys PW, Luscher T (eds), 2nd edition.
  25. Kirchhof P (2009) New antiarrhythmic drugs. In: Cardiac electrophysiology - from cell to bedside. Zipes DP, Jalife J (eds), Saunders, 5th Edition, pp 975-982.
  26. Wittköpper K, Fabritz L, Neef S, Ort K, Grefe C, Unsöld B, Kirchhof P, Maier LS, Hasenfuß G, Dobrev D, Eschenhagen T, El-Armouche A (2009) Conditional overexpression of constitutively active phosphatase-1-inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. J Clin Invest, published online on January 2010, doi:10.1172/JCI40545.

  

COLLABORATIVE WORK

U Schotten / M Allessie (Maastricht, Netherlands); S Kääb (Munich, Germany); U Ravens / D Dobrev (Dresden, Germany); B Knollmann / M Morad (Charlotteville / Georgetown University, USA); M Franz (Georgetown University, USA); W Schmitz & coworkers (Münster, Germany), M Schäfers (Münster, Germany, SFB 656); U Kaupp / D Harzfeld (Research Center Jülich); E & P Carmeliet (Leuven, Belgium); L Jones (Krannert Institute of Cardiology, Indianapolis); H Baba & B Levkau (Essen, Germany); P Ruiz / H Witt / L Thierfelder / A Heuser (Charité Berlin, Germany)

last modified 2010-01-20 10:08